Novel 3,4-Dihydroisocoumarins Inhibit Human P-gp and BCRP in Multidrug Resistant Tumors and Demonstrate Substrate Inhibition of Yeast Pdr5

Multidrug resistance (MDR) in tumors and pathogens remains a major problem in the efficacious treatment of patients by reduction of therapy options and subsequent treatment failure. Various mechanisms are described to be involved in the development of MDR with overexpression of ATP-binding cassette...

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Vydáno v:Front Pharmacol
Hlavní autoři: Sachs, Julia, Döhl, Katja, Weber, Anja, Bonus, Michele, Ehlers, Ferdinand, Fleischer, Edmond, Klinger, Anette, Gohlke, Holger, Pietruszka, Jörg, Schmitt, Lutz, Teusch, Nicole
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2019
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6476959/
https://ncbi.nlm.nih.gov/pubmed/31040786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00400
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