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Dual Inhibition of P-gp and BCRP Improves Oral Topotecan Bioavailability in Rodents
P-glycoprotein (P-gp) inhibition has been studied to overcome multidrug resistance in cancer chemotherapy but failed in clinical trials due to low/toxic effects. Recently, a dual modulation of transporters and natural derivatives have been examined to surmount this limitation. We examined breast can...
שמור ב:
| הוצא לאור ב: | Pharmaceutics |
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| Main Authors: | , , , , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
MDPI
2021
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8071537/ https://ncbi.nlm.nih.gov/pubmed/33921129 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics13040559 |
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