Oral topotecan: bioavailability and effect of food co-administration

The aims of the study were twofold: (1) to evaluate the effect of food on the relative oral bioavailability of topotecan gelatin capsules in patients with solid tumours, and (2) to determine the absolute bioavailability of oral topotecan with reference to the intravenous (i.v.) formulation. The stud...

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Autores principales: Herben, V M M, Rosing, H, Huinink, W W ten Bokkel, Zomeren, D M van, Batchelor, D, Doyle, E, Beusenberg, F D, Beijnen, J H, Schellens, J H M
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 1999
Materias:
Regular Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2363072/
https://ncbi.nlm.nih.gov/pubmed/10424739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6690532
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