Oral topotecan: bioavailability and effect of food co-administration

The aims of the study were twofold: (1) to evaluate the effect of food on the relative oral bioavailability of topotecan gelatin capsules in patients with solid tumours, and (2) to determine the absolute bioavailability of oral topotecan with reference to the intravenous (i.v.) formulation. The stud...

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Main Authors: Herben, V M M, Rosing, H, Huinink, W W ten Bokkel, Zomeren, D M van, Batchelor, D, Doyle, E, Beusenberg, F D, Beijnen, J H, Schellens, J H M
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 1999
Fag:
Regular Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2363072/
https://ncbi.nlm.nih.gov/pubmed/10424739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6690532
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