Phase I and pharmacokinetic study of the combination of topotecan and ifosfamide administered intravenously every 3 weeks

To determine the maximum-tolerated dose (MTD), dose-limiting toxicities, and pharmacokinetics of topotecan administered as a 30-min intravenous (i.v.) infusion over 5 days in combination with a 1-h i.v. infusion of ifosfamide (IF) for 3 consecutive days every 3 weeks. Patients with advanced malignan...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Kerbusch, T, Groenewegen, G, Mathôt, R A A, Herben, V M M, ten Bokkel Huinink, W W, Swart, M, Ambaum, B, Rosing, H, Jansen, S, Voest, E E, Beijnen, J H, Schellens, J H M
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2004
Schlagworte:
Clinical
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2409520/
https://ncbi.nlm.nih.gov/pubmed/15150579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6601861
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