Phase I and pharmacological study of sequential intravenous topotecan and oral etoposide.

We performed a phase I and pharmacological study to determine the maximum tolerated dose (MTD) and dose-limiting toxicities (DLT) of a cytotoxic regimen of the novel topoisomerase I inhibitor topotecan in combination with the topoisomerase II inhibitor etoposide, and to investigate the clinical phar...

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Autors principals: Herben, V. M., ten Bokkel Huinink, W. W., Dubbelman, A. C., Mandjes, I. A., Groot, Y., van Gortel-van Zomeren, D. M., Beijnen, J. H.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 1997
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2228184/
https://ncbi.nlm.nih.gov/pubmed/9400949
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