Phase II and pharmacological study of oral paclitaxel (Paxoral) plus ciclosporin in anthracycline-pretreated metastatic breast cancer

Paclitaxel is an important chemotherapeutic agent for breast cancer. Paclitaxel has high affinity for the P-glycoprotein (P-gp) (drug efflux pump) in the gastrointestinal tract causing low and variable oral bioavailability. Previously, we demonstrated that oral paclitaxel plus the P-gp inhibitor cic...

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Detalhes bibliográficos
Main Authors: Helgason, H H, Kruijtzer, C M F, Huitema, A D R, Marcus, S G, ten Bokkel Huinink, W W, Schot, M E, Schornagel, J H, Beijnen, J H, Schellens, J H M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2006
Assuntos:
Clinical Study
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2360545/
https://ncbi.nlm.nih.gov/pubmed/16969354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6603332
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