Evaluation of the autoinduction of ifosfamide metabolism by a population pharmacokinetic approach using NONMEM

AIMS: This study investigated the population pharmacokinetics of ifosfamide in 15 patients treated for soft tissue sarcoma with 9 or 12 g m(−2) ifosfamide by means of a 72 h continuous i.v. infusion. METHODS: A model was developed using nonlinear mixed effects modelling (NONMEM) to describe the nonl...

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Detalhes bibliográficos
Main Authors: Kerbusch, T, Huitema, A D R, Ouwerkerk, J, Keizer, H J, Mathôt, R A A, Schellens, J H M, Beijnen, J H
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2000
Assuntos:
Population Pharmacokinetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2015043/
https://ncbi.nlm.nih.gov/pubmed/10848719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2000.00217.x
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