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Oral topotecan: bioavailability and effect of food co-administration

The aims of the study were twofold: (1) to evaluate the effect of food on the relative oral bioavailability of topotecan gelatin capsules in patients with solid tumours, and (2) to determine the absolute bioavailability of oral topotecan with reference to the intravenous (i.v.) formulation. The stud...

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Detaylı Bibliyografya
Asıl Yazarlar: Herben, V M M, Rosing, H, Huinink, W W ten Bokkel, Zomeren, D M van, Batchelor, D, Doyle, E, Beusenberg, F D, Beijnen, J H, Schellens, J H M
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 1999
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2363072/
https://ncbi.nlm.nih.gov/pubmed/10424739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6690532
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