Dual Inhibition of P-gp and BCRP Improves Oral Topotecan Bioavailability in Rodents

P-glycoprotein (P-gp) inhibition has been studied to overcome multidrug resistance in cancer chemotherapy but failed in clinical trials due to low/toxic effects. Recently, a dual modulation of transporters and natural derivatives have been examined to surmount this limitation. We examined breast can...

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Detalhes bibliográficos
Publicado no:Pharmaceutics
Main Authors: Lee, Jaeok, Kang, Jiyeon, Kwon, Na-Yun, Sivaraman, Aneesh, Naik, Ravi, Jin, So-Young, Oh, A. Reum, Shin, Jae-Ho, Na, Younghwa, Lee, Kyeong, Lee, Hwa-Jeong
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8071537/
https://ncbi.nlm.nih.gov/pubmed/33921129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics13040559
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