Novel 3,4-Dihydroisocoumarins Inhibit Human P-gp and BCRP in Multidrug Resistant Tumors and Demonstrate Substrate Inhibition of Yeast Pdr5

Multidrug resistance (MDR) in tumors and pathogens remains a major problem in the efficacious treatment of patients by reduction of therapy options and subsequent treatment failure. Various mechanisms are described to be involved in the development of MDR with overexpression of ATP-binding cassette...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Sachs, Julia, Döhl, Katja, Weber, Anja, Bonus, Michele, Ehlers, Ferdinand, Fleischer, Edmond, Klinger, Anette, Gohlke, Holger, Pietruszka, Jörg, Schmitt, Lutz, Teusch, Nicole
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6476959/
https://ncbi.nlm.nih.gov/pubmed/31040786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00400
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