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Selective Inhibition of Aromatase by a Dihydroisocoumarin from Xyris pterygoblephara
Aromatase is a well-established target for the chemoprevention of breast cancer. The dihydroisocoumarin (3R,4R)-(-)-6-methoxy-1-oxo-3-pentyl-3,4-dihydro-1H-isochromen-4-yl acetate (1) (IC(50) = 1.6 ± 0.1 μM), isolated from aerial parts of Xyris pterygoblephara, showed aromatase inhibitory activity....
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2562161/ https://ncbi.nlm.nih.gov/pubmed/18462007 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/np800098f |
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