Loss of atrx cooperates with p53-deficiency to promote the development of sarcomas and other malignancies

The SWI/SNF-family chromatin remodeling protein ATRX is a tumor suppressor in sarcomas, gliomas and other malignancies. Its loss of function facilitates the alternative lengthening of telomeres (ALT) pathway in tumor cells, while it also affects Polycomb repressive complex 2 (PRC2) silencing of its...

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Publicat a:PLoS Genet
Autors principals: Oppel, Felix, Tao, Ting, Shi, Hui, Ross, Kenneth N., Zimmerman, Mark W., He, Shuning, Tong, Guangxiang, Aster, Jon C., Look, A. Thomas
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6476535/
https://ncbi.nlm.nih.gov/pubmed/30970016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008039
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