Overexpression of PDGFRA cooperates with loss of NF1 and p53 to accelerate the molecular pathogenesis of malignant peripheral nerve sheath tumors

Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive, frequently metastatic sarcomas that are associated with neurofibromatosis type 1 (NF1), a prominent inherited genetic disease in humans. Although loss of the NF1 gene predisposes to MPNST induction, relatively long tumor latency in NF...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Ki, D H, He, S, Rodig, S, Look, A T
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5332555/
https://ncbi.nlm.nih.gov/pubmed/27477693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2016.269
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