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tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors
TP53 is the most frequently mutated tumor suppressor gene in human cancer, with nearly 50% of all tumors exhibiting a loss-of-function mutation. To further elucidate the genetic pathways involving TP53 and cancer, we have exploited the zebrafish, a powerful vertebrate model system that is amenable t...
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| Veröffentlicht in: | Proc Natl Acad Sci U S A |
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| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2005
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC544293/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15630097/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0406252102 |
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