tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors

TP53 is the most frequently mutated tumor suppressor gene in human cancer, with nearly 50% of all tumors exhibiting a loss-of-function mutation. To further elucidate the genetic pathways involving TP53 and cancer, we have exploited the zebrafish, a powerful vertebrate model system that is amenable t...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Berghmans, Stéphane, Murphey, Ryan D., Wienholds, Erno, Neuberg, Donna, Kutok, Jeffery L., Fletcher, Christopher D. M., Morris, John P., Liu, Ting Xi, Schulte-Merker, Stefan, Kanki, John P., Plasterk, Ronald, Zon, Leonard I., Look, A. Thomas
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2005
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC544293/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15630097/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0406252102
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