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Heat shock-inducible Cre/Lox approaches to induce diverse types of tumors and hyperplasia in transgenic zebrafish

RAS family members are among the most frequently mutated oncogenes in human cancers. Given the utility of zebrafish in both chemical and genetic screens, developing RAS-induced cancer models will make large-scale screens possible to understand further the molecular mechanisms underlying malignancy....

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Detalhes bibliográficos
Main Authors: Le, Xiuning, Langenau, David M., Keefe, Matthew D., Kutok, Jeffery L., Neuberg, Donna S., Zon, Leonard I.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1890508/
https://ncbi.nlm.nih.gov/pubmed/17517602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0611302104
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