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Loss of function tp53 mutations do not accelerate the onset of myc-induced T-ALL in the zebrafish
The TP53 tumour suppressor is activated in response to distinct stimuli, including an ARF-dependent response to oncogene stress and an ATM/ATR-dependent response to DNA damage. In human T-cell acute lymphoblastic leukaemia (T-ALL), TP53-dependent tumour suppression is typically disabled via bialleli...
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| Publicado no: | Br J Haematol |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4234197/ https://ncbi.nlm.nih.gov/pubmed/24690081 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bjh.12851 |
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