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Spindle assembly checkpoint and p53 deficiencies cooperate for tumorigenesis in mice
The spindle assembly checkpoint (SAC) guards against chromosomal mis-segregation during mitosis. To investigate the role of SAC in tumor development, mice heterozygously knocked-out for the mitotic arrest deficient (Mad) genes Mad1 and/or Mad2 were mated with p53(+/−) mice. Increased tumor frequenci...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2706662/ https://ncbi.nlm.nih.gov/pubmed/19065665 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.24094 |
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