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Loss of atrx cooperates with p53-deficiency to promote the development of sarcomas and other malignancies
The SWI/SNF-family chromatin remodeling protein ATRX is a tumor suppressor in sarcomas, gliomas and other malignancies. Its loss of function facilitates the alternative lengthening of telomeres (ALT) pathway in tumor cells, while it also affects Polycomb repressive complex 2 (PRC2) silencing of its...
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| Yayımlandı: | PLoS Genet |
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| Asıl Yazarlar: | , , , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Public Library of Science
2019
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6476535/ https://ncbi.nlm.nih.gov/pubmed/30970016 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008039 |
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