Arsenite malignantly transforms human prostate epithelial cells in vitro by gene amplification of mutated KRAS

Inorganic arsenic is an environmental human carcinogen of several organs including the urinary tract. RWPE-1 cells are immortalized, non-tumorigenic, human prostate epithelia that become malignantly transformed into the CAsE-PE line after continuous in vitro exposure to 5μM arsenite over a period of...

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Enregistré dans:
Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Merrick, B. Alex, Phadke, Dhiral P., Bostrom, Meredith A., Shah, Ruchir R., Wright, Garron M., Wang, Xinguo, Gordon, Oksana, Pelch, Katherine E., Auerbach, Scott S., Paules, Richard S., DeVito, Michael J., Waalkes, Michael P., Tokar, Erik J.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2019
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6476498/
https://ncbi.nlm.nih.gov/pubmed/31009485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0215504
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