RNA-Seq Profiling Reveals Novel Hepatic Gene Expression Pattern in Aflatoxin B1 Treated Rats

Deep sequencing was used to investigate the subchronic effects of 1 ppm aflatoxin B1 (AFB1), a potent hepatocarcinogen, on the male rat liver transcriptome prior to onset of histopathological lesions or tumors. We hypothesized RNA-Seq would reveal more differentially expressed genes (DEG) than micro...

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Detalhes bibliográficos
Main Authors: Merrick, B. Alex, Phadke, Dhiral P., Auerbach, Scott S., Mav, Deepak, Stiegelmeyer, Suzy M., Shah, Ruchir R., Tice, Raymond R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3632591/
https://ncbi.nlm.nih.gov/pubmed/23630614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0061768
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