Assessment of rimonabant-like adverse effects of purported CB1R neutral antagonist / CB2R agonist aminoalkylindole derivatives in mice

BACKGROUND: Cannabinoids may be useful in the treatment of CNS disorders including drug abuse and addiction, where both CB1R antagonists / inverse agonists and CB2R agonists have shown preclinical efficacy. TV-5–249 and TV-6–41, two novel aminoalkylindoles with dual action as neutral CB1R antagonist...

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Udgivet i:Drug Alcohol Depend
Main Authors: S, Tai, T, Vasiljevik, A, Sherwood, S, Eddington, CD, Wilson, TE, Prisinzano, WE, Fantegrossi
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6475911/
https://ncbi.nlm.nih.gov/pubmed/30300803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.drugalcdep.2018.08.011
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