Monohydroxylated metabolites of the K2 synthetic cannabinoid JWH-073 retain intermediate to high cannabinoid 1 receptor (CB1R) affinity and exhibit neutral antagonist to partial agonist activity

K2 and several similar purported “incense products” spiked with synthetic cannabinoids are abused as cannabis substitutes. We hypothesized that metabolism of JWH-073, a prevalent cannabinoid found in K2, contributes to toxicity associated with K2 use. Competition receptor binding studies and G-prote...

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Main Authors: Brents, Lisa K., Gallus-Zawada, Anna, Radominska-Pandya, Anna, Vasiljevik, Tamara, Prisinzano, Thomas E., Fantegrossi, William E., Moran, Jeffery H., Prather, Paul L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3288656/
https://ncbi.nlm.nih.gov/pubmed/22266354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2012.01.004
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