Repeated administration of phytocannabinoid Δ(9)-THC or synthetic cannabinoids JWH-018 and JWH-073 induces tolerance to hypothermia but not locomotor suppression in mice, and reduces CB1 receptor expression and function in a brain region-specific manner

These studies probed the relationship between intrinsic efficacy and tolerance / cross-tolerance between Δ(9)-THC and synthetic cannabinoid drugs of abuse (SCBs) by examining in vivo effects and cellular changes concomitant with their repeated administration in mice. Dose-effect relationships for hy...

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Publicado en:Pharmacol Res
Main Authors: Tai, S, Hyatt, WS, Gu, C, Franks, LN, Vasiljevik, T, Brents, LK, Prather, PL, Fantegrossi, WE
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4684449/
https://ncbi.nlm.nih.gov/pubmed/26361728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.phrs.2015.09.006
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