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Repeated administration of phytocannabinoid Δ(9)-THC or synthetic cannabinoids JWH-018 and JWH-073 induces tolerance to hypothermia but not locomotor suppression in mice, and reduces CB1 receptor expression and function in a brain region-specific manner
These studies probed the relationship between intrinsic efficacy and tolerance / cross-tolerance between Δ(9)-THC and synthetic cannabinoid drugs of abuse (SCBs) by examining in vivo effects and cellular changes concomitant with their repeated administration in mice. Dose-effect relationships for hy...
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| Publicat a: | Pharmacol Res |
|---|---|
| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4684449/ https://ncbi.nlm.nih.gov/pubmed/26361728 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.phrs.2015.09.006 |
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