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Assessment of rimonabant-like adverse effects of purported CB1R neutral antagonist / CB2R agonist aminoalkylindole derivatives in mice
BACKGROUND: Cannabinoids may be useful in the treatment of CNS disorders including drug abuse and addiction, where both CB1R antagonists / inverse agonists and CB2R agonists have shown preclinical efficacy. TV-5–249 and TV-6–41, two novel aminoalkylindoles with dual action as neutral CB1R antagonist...
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| Pubblicato in: | Drug Alcohol Depend |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6475911/ https://ncbi.nlm.nih.gov/pubmed/30300803 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.drugalcdep.2018.08.011 |
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