Ubiquitin C-terminal hydrolase L1 (UCH-L1) loss causes neurodegeneration by altering protein turnover in the first postnatal weeks

Ubiquitin C-terminal hydrolase L1 (UCH-L1) is one of the most abundant and enigmatic enzymes of the CNS. Based on existing UCH-L1 knockout models, UCH-L1 is thought to be required for the maintenance of axonal integrity, but not for neuronal development despite its high expression in neurons. Severa...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Reinicke, Anna T., Laban, Karoline, Sachs, Marlies, Kraus, Vanessa, Walden, Michael, Damme, Markus, Sachs, Wiebke, Reichelt, Julia, Schweizer, Michaela, Janiesch, Philipp Christoph, Duncan, Kent E., Saftig, Paul, Rinschen, Markus M., Morellini, Fabio, Meyer-Schwesinger, Catherine
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2019
Konular:
PNAS Plus
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6475369/
https://ncbi.nlm.nih.gov/pubmed/30923110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1812413116
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