Ubiquitin C-terminal hydrolase L1 (UCH-L1) loss causes neurodegeneration by altering protein turnover in the first postnatal weeks

Ubiquitin C-terminal hydrolase L1 (UCH-L1) is one of the most abundant and enigmatic enzymes of the CNS. Based on existing UCH-L1 knockout models, UCH-L1 is thought to be required for the maintenance of axonal integrity, but not for neuronal development despite its high expression in neurons. Severa...

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Bibliografische gegevens
Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Reinicke, Anna T., Laban, Karoline, Sachs, Marlies, Kraus, Vanessa, Walden, Michael, Damme, Markus, Sachs, Wiebke, Reichelt, Julia, Schweizer, Michaela, Janiesch, Philipp Christoph, Duncan, Kent E., Saftig, Paul, Rinschen, Markus M., Morellini, Fabio, Meyer-Schwesinger, Catherine
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2019
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PNAS Plus
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6475369/
https://ncbi.nlm.nih.gov/pubmed/30923110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1812413116
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