Validation of Plasmodium falciparum deoxyhypusine synthase as an antimalarial target

BACKGROUND: Hypusination is an essential post-translational modification in eukaryotes. The two enzymes required for this modification, namely deoxyhypusine synthase (DHS) and deoxyhypusine hydrolase are also conserved. Plasmodium falciparum human malaria parasites possess genes for both hypusinatio...

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Bibliographic Details
Published in:PeerJ
Main Authors: Aroonsri, Aiyada, Posayapisit, Navaporn, Kongsee, Jindaporn, Siripan, Onsiri, Vitsupakorn, Danoo, Utaida, Sugunya, Uthaipibull, Chairat, Kamchonwongpaisan, Sumalee, Shaw, Philip J.
Format: Artigo
Language:Inglês
Published: PeerJ Inc. 2019
Subjects:
Biochemistry
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6475138/
https://ncbi.nlm.nih.gov/pubmed/31024761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7717/peerj.6713
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