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Esterification Delivers a Functional Enzyme into a Human Cell
A major hurdle in chemical biology is the delivery of native proteins into the cytosol of mammalian cells. Herein, we report that esterification of the carboxyl groups of an enzyme with a diazo compound enables not only its passage into the cytosol, but also the retention of its catalytic activity t...
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| Publicado en: | ACS Chem Biol |
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| Autores principales: | , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6474803/ https://ncbi.nlm.nih.gov/pubmed/30830748 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00033 |
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