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Esterification Delivers a Functional Enzyme into a Human Cell

A major hurdle in chemical biology is the delivery of native proteins into the cytosol of mammalian cells. Herein, we report that esterification of the carboxyl groups of an enzyme with a diazo compound enables not only its passage into the cytosol, but also the retention of its catalytic activity t...

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Publicat a:ACS Chem Biol
Autors principals: Ressler, Valerie T., Mix, Kalie A., Raines, Ronald T.
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6474803/
https://ncbi.nlm.nih.gov/pubmed/30830748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00033
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