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The Less the Better: How Suppressed Base Addition Boosts Production of Monoclonal Antibodies With Chinese Hamster Ovary Cells

Biopharmaceutical production processes strive for the optimization of economic efficiency. Among others, the maximization of volumetric productivity is a key criterion. Typical parameters such as partial pressure of CO(2) (pCO(2)) and pH are known to influence the performance although reasons are no...

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Dettagli Bibliografici
Pubblicato in:Front Bioeng Biotechnol
Autori principali: Becker, Max, Junghans, Lisa, Teleki, Attila, Bechmann, Jan, Takors, Ralf
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2019
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6470187/
https://ncbi.nlm.nih.gov/pubmed/31032253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fbioe.2019.00076
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