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Methylthioadenosine (MTA) boosts cell‐specific productivities of Chinese hamster ovary cultures: dosage effects on proliferation, cell cycle and gene expression

A major goal for process and cell engineering in the biopharmaceutical industry is enhancing production through increasing volumetric and cell‐specific productivities (CSP). Here, we present 5′‐deoxy‐5′‐(methylthio)adenosine (MTA), the degradation product of S‐(5′‐adenosyl)‐L‐methionine (SAM), as a...

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Détails bibliographiques
Publié dans:FEBS Open Bio
Auteurs principaux: Verhagen, Natascha, Zieringer, Julia, Takors, Ralf
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2020
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7714083/
https://ncbi.nlm.nih.gov/pubmed/33128321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/2211-5463.13019
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