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Methylthioadenosine (MTA) boosts cell‐specific productivities of Chinese hamster ovary cultures: dosage effects on proliferation, cell cycle and gene expression

A major goal for process and cell engineering in the biopharmaceutical industry is enhancing production through increasing volumetric and cell‐specific productivities (CSP). Here, we present 5′‐deoxy‐5′‐(methylthio)adenosine (MTA), the degradation product of S‐(5′‐adenosyl)‐L‐methionine (SAM), as a...

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Detalhes bibliográficos
Publicado no:FEBS Open Bio
Main Authors: Verhagen, Natascha, Zieringer, Julia, Takors, Ralf
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7714083/
https://ncbi.nlm.nih.gov/pubmed/33128321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/2211-5463.13019
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