PDADMAC flocculation of Chinese hamster ovary cells: Enabling a centrifuge-less harvest process for monoclonal antibodies

High titer (>10 g/L) monoclonal antibody (mAb) cell culture processes are typically achieved by maintaining high viable cell densities over longer culture durations. A corresponding increase in the solids and sub-micron cellular debris particle levels are also observed. This higher burden of soli...

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Detalhes bibliográficos
Publicado no:MAbs
Main Authors: McNerney, Thomas, Thomas, Anne, Senczuk, Anna, Petty, Krista, Zhao, Xiaoyang, Piper, Rob, Carvalho, Juliane, Hammond, Matthew, Sawant, Satin, Bussiere, Jeanine
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2015
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Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622464/
https://ncbi.nlm.nih.gov/pubmed/25706650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2015.1007824
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