Antagonists for Constitutively Active Mutant Estrogen Receptors: Insights into the Roles of Antiestrogen-Core and Side-Chain

A major risk for patients having estrogen receptor α (ERα)-positive breast cancer is the recurrence of drug-resistant metastases after initial successful treatment with endocrine therapies. Recent studies have implicated a number of activating mutations in the ligand-binding domain of ERα that stabi...

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Publicat a:ACS Chem Biol
Autors principals: Sharma, Abhishek, Toy, Weiyi, Guillen, Valeria Sanabria, Sharma, Naina, Min, Jian, Carlson, Kathryn E., Mayne, Christopher G., Lin, Shengjia, Sabio, Michael, Greene, Geoffrey, Katzenellenbogen, Benita S., Chandarlapaty, Sarat, Katzenellenbogen, John A.
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6469989/
https://ncbi.nlm.nih.gov/pubmed/30404440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.8b00877
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