New Class of Selective Estrogen Receptor Degraders (SERDs): Expanding the Toolbox of PROTAC Degrons

[Image: see text] An effective endocrine therapy for breast cancer is to selectively and effectively degrade the estrogen receptor (ER). Up until now, there have been largely only two molecular scaffolds capable of doing this. In this study, we have developed new classes of scaffolds that possess se...

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Bibliografiset tiedot
Julkaisussa:ACS Med Chem Lett
Päätekijät: Wang, Lucia, Guillen, Valeria S., Sharma, Naina, Flessa, Kevin, Min, Jian, Carlson, Kathryn E., Toy, Weiyi, Braqi, Sara, Katzenellenbogen, Benita S., Katzenellenbogen, John A., Chandarlapaty, Sarat, Sharma, Abhishek
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Chemical Society 2018
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6088359/
https://ncbi.nlm.nih.gov/pubmed/30128071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00106
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