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Characterization of the Pharmacophore Properties of Novel Selective Estrogen Receptor Downregulators (SERDs)
Selective estrogen receptor (ER) downregulators (SERDs) reduce ERα protein levels as well as block ER activity, and therefore are promising therapeutic agents for the treatment of hormone refractory breast cancer. Starting with the triarylethylene acrylic acid SERD 4, we have investigated how altera...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2916745/ https://ncbi.nlm.nih.gov/pubmed/20334372 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm100047k |
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