Novel Selective Estrogen Receptor Downregulators (SERDs) Developed Against Treatment-Resistant Breast Cancer

Resistance to the selective estrogen receptor modulator (SERM) tamoxifen and to aromatase inhibitors that lower circulating estradiol occurs in up to 50% of patients, generally leading to an endocrine-independent ER+ phenotype. Selective ER downregulators (SERDs) are able to ablate ER and thus theor...

Full description

Saved in:
Bibliographic Details
Published in:J Med Chem
Main Authors: Xiong, Rui, Zhao, Jiong, Gutgesell, Lauren M., Wang, Yueting, Lee, Sue, Karumudi, Bhargava, Zhao, Huiping, Lu, Yunlong, Tonetti, Debra A., Thatcher, Gregory R. J.
Format: Artigo
Language:Inglês
Published: 2017
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5786431/
https://ncbi.nlm.nih.gov/pubmed/28117994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b01355
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items