Novel Selective Estrogen Receptor Downregulators (SERDs) Developed Against Treatment-Resistant Breast Cancer

Resistance to the selective estrogen receptor modulator (SERM) tamoxifen and to aromatase inhibitors that lower circulating estradiol occurs in up to 50% of patients, generally leading to an endocrine-independent ER+ phenotype. Selective ER downregulators (SERDs) are able to ablate ER and thus theor...

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Detaylı Bibliyografya
Yayımlandı:J Med Chem
Asıl Yazarlar: Xiong, Rui, Zhao, Jiong, Gutgesell, Lauren M., Wang, Yueting, Lee, Sue, Karumudi, Bhargava, Zhao, Huiping, Lu, Yunlong, Tonetti, Debra A., Thatcher, Gregory R. J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5786431/
https://ncbi.nlm.nih.gov/pubmed/28117994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b01355
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