Structurally novel antiestrogens elicit differential responses from constitutively active mutant estrogen receptors in breast cancer cells and tumors

Many ERα-positive breast cancers develop resistance to endocrine therapy via mutation of estrogen receptors (ER) whose constitutive activation is associated with shorter patient survival. Because there is now a clinical need for new antiestrogens (AE) against these mutant ER, we describe here our de...

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Publicado no:Cancer Res
Main Authors: Zhao, Yuechao, Laws, Mary J., Guillen, Valeria Sanabria, Ziegler, Yvonne, Min, Jian, Sharma, Abhishek, Kim, Sung Hoon, Chu, David, Park, Ben Ho, Oesterreich, Steffi, Mao, Chengjian, Shapiro, David J., Nettles, Kendall W., Katzenellenbogen, John A., Katzenellenbogen, Benita S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5645250/
https://ncbi.nlm.nih.gov/pubmed/28904064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-1265
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