Inactivation of Cyclic AMP Response Element Transcription Caused by Constitutive p38 Activation Is Mediated by Hyperphosphorylation-Dependent CRTC2 Nucleocytoplasmic Transport

The p38 signal transduction pathway can be activated transiently or constitutively, depending on the contexts in which the activation occurs. However, the biological consequence of constitutive activation of p38 is largely unknown. After screening 300 transcriptional cofactors, we identified CRTC2 a...

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Опубликовано в: :Mol Cell Biol
Главные авторы: Ma, Huabin, Liu, Zeyuan, Zhong, Chuan-Qi, Liu, Yifei, Zhang, Zhirong, Liang, Yaoji, Li, Jingxian, Han, Shoufa, Han, Jiahuai
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2019
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6469919/
https://ncbi.nlm.nih.gov/pubmed/30782776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00554-18
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