Evaluation of 1,2,3-Triazoles as Amide Bioisosteres In Cystic Fibrosis Transmembrane Conductance Regulator Modulators VX-770 and VX-809

The 1,2,3-triazole has been successfully utilized as an amide bioisostere in multiple therapeutic contexts. Based on this precedent, triazole analogs derived from VX-809 and VX-770, prominent amide-containing modulators of the cystic fibrosis transmembrane conductance regulator (CFTR), were synthesi...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Chemistry
Asıl Yazarlar: Doiron, Jake E., Le, Christina A., Ody, Britton K., Brace, Jonathon B., Post, Savannah J., Thacker, Nathan L., Hill, Harrison M., Breton, Gary W., Mulder, Matthew J., Chang, Sichen, Bridges, Thomas M., Tang, Liping, Wang, Wei, Rowe, Steven M., Aller, Stephen G., Turlington, Mark
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6469399/
https://ncbi.nlm.nih.gov/pubmed/30650214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201805919
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller