Evaluation of 1,2,3-Triazoles as Amide Bioisosteres In Cystic Fibrosis Transmembrane Conductance Regulator Modulators VX-770 and VX-809

The 1,2,3-triazole has been successfully utilized as an amide bioisostere in multiple therapeutic contexts. Based on this precedent, triazole analogs derived from VX-809 and VX-770, prominent amide-containing modulators of the cystic fibrosis transmembrane conductance regulator (CFTR), were synthesi...

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Publicat a:Chemistry
Autors principals: Doiron, Jake E., Le, Christina A., Ody, Britton K., Brace, Jonathon B., Post, Savannah J., Thacker, Nathan L., Hill, Harrison M., Breton, Gary W., Mulder, Matthew J., Chang, Sichen, Bridges, Thomas M., Tang, Liping, Wang, Wei, Rowe, Steven M., Aller, Stephen G., Turlington, Mark
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6469399/
https://ncbi.nlm.nih.gov/pubmed/30650214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201805919
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