Evaluation of 1,2,3-Triazoles as Amide Bioisosteres In Cystic Fibrosis Transmembrane Conductance Regulator Modulators VX-770 and VX-809

The 1,2,3-triazole has been successfully utilized as an amide bioisostere in multiple therapeutic contexts. Based on this precedent, triazole analogs derived from VX-809 and VX-770, prominent amide-containing modulators of the cystic fibrosis transmembrane conductance regulator (CFTR), were synthesi...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Chemistry
Hauptverfasser: Doiron, Jake E., Le, Christina A., Ody, Britton K., Brace, Jonathon B., Post, Savannah J., Thacker, Nathan L., Hill, Harrison M., Breton, Gary W., Mulder, Matthew J., Chang, Sichen, Bridges, Thomas M., Tang, Liping, Wang, Wei, Rowe, Steven M., Aller, Stephen G., Turlington, Mark
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6469399/
https://ncbi.nlm.nih.gov/pubmed/30650214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201805919
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge