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1,2,3-Triazoles as amide bioisosteres: discovery of a new class of potent HIV-1 Vif antagonists
RN-18–based Viral infectivity factor, Vif antagonists reduce viral infectivity by rescuing APOBEC3G (A3G) expression and enhancing A3G-dependent Vif degradation. Replacement of amide functionality in RN-18 (IC(50) = 6 μM) by isosteric heterocycles resulted in the discovery of a 1,2,3-trizole, 1d (IC...
Guardat en:
| Publicat a: | J Med Chem |
|---|---|
| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5534211/ https://ncbi.nlm.nih.gov/pubmed/27509004 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b00247 |
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