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Small-molecule inhibition of HIV-1 Vif
The HIV-1 protein Vif, essential for in vivo viral replication1–4, targets the human DNA-editing enzyme, APOBEC3G (A3G)5, which inhibits replication of retroviruses and hepatitis B virus6,7. As Vif has no known cellular homologs, it is an attractive, yet unrealized, target for antiviral intervention...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2693000/ https://ncbi.nlm.nih.gov/pubmed/18806783 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.1496 |
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