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SAR and Lead Optimization of an HIV-1 Vif-APOBEC3G Axis Inhibitor
[Image: see text] We describe structure–activity relationship and optimization studies of RN-18, an HIV-1 Vif-APOBEC3G axis inhibitor. Targeted modifications of RN-18 ring C, ring B, ring A, bridge A–B, and bridge B–C were performed to identify the crucial structural features, which generated new in...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American
Chemical Society
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3922209/ https://ncbi.nlm.nih.gov/pubmed/24533175 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300037k |
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