SAR and Lead Optimization of an HIV-1 Vif-APOBEC3G Axis Inhibitor

[Image: see text] We describe structure–activity relationship and optimization studies of RN-18, an HIV-1 Vif-APOBEC3G axis inhibitor. Targeted modifications of RN-18 ring C, ring B, ring A, bridge A–B, and bridge B–C were performed to identify the crucial structural features, which generated new in...

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Autori principali: Mohammed, Idrees, Parai, Maloy K., Jiang, Xinpeng, Sharova, Natalia, Singh, Gatikrushna, Stevenson, Mario, Rana, Tariq M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2012
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3922209/
https://ncbi.nlm.nih.gov/pubmed/24533175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300037k
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