From identification to functional characterization of cyriotoxin‐1a, an antinociceptive toxin from the spider Cyriopagopus schioedtei

BACKGROUND AND PURPOSE: The Na(V)1.7 channel is highly expressed in dorsal root ganglia of the sensory nervous system and plays a central role in the pain signalling process. We investigated a library prepared from original venoms of 117 different animals to identify new selective inhibitors of this...

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Bibliografiske detaljer
Udgivet i:Br J Pharmacol
Main Authors: Gonçalves, Tânia C., Benoit, Evelyne, Kurz, Michael, Lucarain, Laetitia, Fouconnier, Sophie, Combemale, Stéphanie, Jaquillard, Lucie, Schombert, Brigitte, Chambard, Jean‐Marie, Boukaiba, Rachid, Hessler, Gerhard, Bohme, Andrees, Bialy, Laurent, Hourcade, Stéphane, Béroud, Rémy, De Waard, Michel, Servent, Denis, Partiseti, Michel
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2019
Fag:
Research Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6468265/
https://ncbi.nlm.nih.gov/pubmed/30784059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14628
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