From identification to functional characterization of cyriotoxin‐1a, an antinociceptive toxin from the spider Cyriopagopus schioedtei

BACKGROUND AND PURPOSE: The Na(V)1.7 channel is highly expressed in dorsal root ganglia of the sensory nervous system and plays a central role in the pain signalling process. We investigated a library prepared from original venoms of 117 different animals to identify new selective inhibitors of this...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Gonçalves, Tânia C., Benoit, Evelyne, Kurz, Michael, Lucarain, Laetitia, Fouconnier, Sophie, Combemale, Stéphanie, Jaquillard, Lucie, Schombert, Brigitte, Chambard, Jean‐Marie, Boukaiba, Rachid, Hessler, Gerhard, Bohme, Andrees, Bialy, Laurent, Hourcade, Stéphane, Béroud, Rémy, De Waard, Michel, Servent, Denis, Partiseti, Michel
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6468265/
https://ncbi.nlm.nih.gov/pubmed/30784059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14628
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