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High-resolution crystal structures of ribosome-bound chloramphenicol and erythromycin provide the ultimate basis for their competition
The 70S ribosome is a major target for antibacterial drugs. Two of the classical antibiotics, chloramphenicol (CHL) and erythromycin (ERY), competitively bind to adjacent but separate sites on the bacterial ribosome: the catalytic peptidyl transferase center (PTC) and the nascent polypeptide exit tu...
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| Publicado no: | RNA |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6467010/ https://ncbi.nlm.nih.gov/pubmed/30733327 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.069260.118 |
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