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Structure of Erm-modified 70S ribosome reveals the mechanism of macrolide resistance.

Many antibiotics inhibit bacterial growth by binding to the ribosome and interfering with protein biosynthesis. Macrolides represent one of the most successful classes of ribosome-targeting antibiotics. The main clinically-relevant mechanism of resistance to macrolides is dimethylation of the 23S rR...

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Detalhes bibliográficos
Publicado no:Nat Chem Biol
Main Authors: Svetlov, Maxim S., Syroegin, Egor A., Aleksandrova, Elena V., Atkinson, Gemma C., Gregory, Steven T., Mankin, Alexander S., Polikanov, Yury S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7990689/
https://ncbi.nlm.nih.gov/pubmed/33462493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-020-00715-0
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